A Guide to ​Boosting the Health Benefits of CBD with Terpenes

Posted by TL Knowledge Team on 24th May 2023

A Guide to ​Boosting the Health Benefits of CBD with Terpenes


Cannabidiol (CBD) and terpenes have created a buzz in the health and wellness sector, as these compounds from the cannabis plant show significant promise in treating various ailments. This in-depth guide explores how the interaction between CBD and terpenes can enhance the benefits of each other.

CBD: A Deeper Look

1. Anxiety and Depression: CBD's interaction with the serotonin receptors can alleviate anxiety and depression. Blessing et al. (2015) found that CBD effectively reduced social anxiety in patients by impacting the 5-HT1A receptors, enhancing mood stabilisation and providing calming effects.

2. Chronic Pain and Inflammation: Russo (2008) explained how CBD interacts with the body's endocannabinoid receptors to reduce chronic pain and inflammation. Through its anti-inflammatory properties, CBD regulates immune cell function and suppresses cytokine production, making it an effective treatment for arthritis and other inflammatory conditions.

3. Neuroprotective Properties: Research by Mecha et al. (2013) demonstrated that CBD provides protection against inflammation in a viral model of multiple sclerosis. By reducing the inflammatory environment in the central nervous system, CBD preserves myelin sheath and aids in neuroprotection.

4. Heart Health: CBD has shown potential in supporting heart health. A study by Jadoon et al. (2017) discovered that a single dose of CBD reduced blood pressure in healthy volunteers, potentially reducing the risk of stroke and heart attack.

Terpenes: More Than Just Aroma

1. Limonene: Known for its uplifting and stress-reducing effects, limonene has shown potential in enhancing immune function (Komori et al., 1995). Its anti-anxiety properties make it a valuable addition to mental health treatments.

2. Myrcene: Myrcene possesses potent anti-inflammatory and analgesic properties. A study by Rao et al. (1990) demonstrated myrcene's efficacy in reducing nociception, highlighting its importance in pain management. Pain is the subjective experience one feels as a result of the activation of these pathways.

3. Linalool: Known for its calming effects, linalool has been found to enhance the body's immune response (Peana et al., 2002). Its anti-inflammatory properties can be used to treat conditions like arthritis.

CBD and Terpenes: A Synergistic Relationship

1. Enhanced Absorption: The presence of terpenes has been found to increase CBD’s permeability. A study by Gallily et al. (2015) found that the bell-shaped dose-response of CBD was overcome by using cannabis extract enriched with CBD, allowing better absorption into the bloodstream. The study found that pure CBD has a bell-shaped dose-response, meaning that its effectiveness increases with dose up to a certain point and then decreases. By using cannabis extract enriched with CBD (which includes terpenes), the researchers were able to overcome this bell-shaped curve, achieving a linear dose-response. 

2. Expanded Therapeutic Range: The combination of CBD with specific terpenes can result in targeted therapeutic effects. For example, pairing CBD with limonene can enhance anxiety treatment, while myrcene can boost pain relief.

Applications and Ailments

1. Chronic Pain Management: Myrcene and caryophyllene, combined with CBD, can significantly amplify pain-relief effects. This combination targets multiple pathways in the pain response, leading to an effective, natural treatment for chronic pain.

2. Mood Enhancement: Limonene and linalool, paired with CBD, provide a holistic approach to treating anxiety and depression. Their synergistic effect activates serotonin receptors, enhancing mood stabilisation.

3. Sleep Aid: The combination of myrcene with CBD can act as a potent sleep aid. By impacting the receptors that regulate sleep, this pairing can effectively address insomnia and other sleep disorders.

4. Heart Health: Pinene, one of the prominent terpenes found in various plants, has been studied for its potential anti-inflammatory properties and effects on blood circulation. While more research is needed, some suggest that pinene could have implications for overall heart health, especially when considered as part of a broader wellness strategy involving CBD and other compounds.

The intersection of CBD and terpenes offers a revolutionary pathway to holistic health and wellness. With a solid understanding of these compounds and continuous scientific research, individuals can tailor their healing experience, harnessing the full potential of these natural substances.

Research Citations

  1. Blessing, E. M., et al. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics, 12(4), 825-836.
  2. Russo, E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and Clinical Risk Management, 4(1), 245.
  3. Mecha, M., et al. (2013). Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis. Frontiers in Neurology, 4, 128.
  4. Jadoon, K. A., et al. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI Insight, 2(12).
  5. Komori, T., et al. (1995). Effects of citrus fragrance on immune function and depressive states. Neuroimmunomodulation, 2(3), 174-180.
  6. Rao, V. S., et al. (1990). Effect of myrcene on nociception in mice. Journal of Pharmacy and Pharmacology, 42(12), 877-878.
  7. Peana, A. T., et al. (2002). Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils. Phytomedicine, 9(8), 721-726.
  8. Gallily, R., et al. (2015). Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol. Pharmacology & Pharmacy, 6, 75-85.